Born John Christopher Depp in Owensboro, Kentucky, on June 9, 1963, Johnny Depp was raised in Florida. He dropped out of school at age 15 in the hopes of becoming a rock musician. He fronted a series of garage bands including The Kids, which once opened for Iggy Pop. Depp got into acting after a visit to Los Angeles, California, with his former wife, Lori Anne Allison (Lori A. Depp), who introduced him to actor Nicolas Cage. He made his film debut in A Nightmare on Elm Street (1984). In 1987 he shot to stardom when he replaced Jeff Yagher in the role of undercover cop Tommy Hanson in the popular TV series "21 Jump Street" (1987).

In 1990, after numerous roles in teen-oriented films, his first of a handful of great collaborations with director Tim Burton came about when Depp played the title role in Edward Scissorhands (1990). Following the film's success, Depp carved a niche for himself as a serious, somewhat dark, idiosyncratic performer, consistently selecting roles that surprised critics and audiences alike. He continued to gain critical acclaim and increasing popularity by appearing in many features before re-joining with Burton in the lead role of Ed Wood (1994). In 1997 he played an undercover FBI agent in the fact-based film Donnie Brasco (1997), opposite Al Pacino; in 1998 he appeared in Fear and Loathing in Las Vegas (1998), directed by Terry Gilliam; and then, in 1999, he appeared in the sci-fi/horror film The Astronaut's Wife (1999). The same year he teamed up again with Burton in Sleepy Hollow (1999), brilliantly portraying Ichabod Crane.

Depp has played many characters in his career, including another fact-based one, Insp. Fred Abberline in From Hell (2001). He stole the show from screen greats such as Antonio Banderas in the finale to Robert Rodriguez's "mariachi" trilogy, Once Upon a Time in Mexico (2003). In that same year he starred in the marvelous family blockbuster Pirates of the Caribbean: The Curse of the Black Pearl (2003), playing a character that only the likes of Depp could pull off: the charming, conniving and roguish Capt. Jack Sparrow. Now Depp is collaborating again with Burton in a screen adaptation of Roald Dahl's novel, Charlie and the Chocolate Factory (2005).

Off-screen, Depp has dated several female celebrities, and has been engaged to Sherilyn Fenn, Jennifer Grey, Winona Ryder and Kate Moss. He was married to Lori Anne Allison in 1983 but they divorced her in 1985. Depp is living with French singer-actress Vanessa Paradis, with whom he has two children: Lily-Rose Melody, born in 1999 and Jack, born in 2002.